Clinicaltrials.gov was searched for registered review protocols. The keywords and phrases “palmitoylethanolamide” and “discomfort” resulted in 13 entries, of which three were being concluded. None of these fulfilled our eligibility standards.Costa and colleagues [178] have proposed that PEA was able to cut back mechanical allodynia and ther

2015). These reports, taken together, counsel that, Whilst a direct activation of GPR55 or PPAR?? occurs, PEA can generate its anti?inflammatory action during the intestine also by means of oblique activation of CB1 and CB2 receptors, likely resulting from the power of the compound to potentiate the action of endocannabinoids at these receptors.The

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